Patched 1 Antikörper (AA 1214-1312)

Produktnummer ABIN3015343

Dieses Anti-Patched 1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von Patched 1 in WB, IHC und IF. Geeignet für Human.

Kurzübersicht für Patched 1 Antikörper (AA 1214-1312) (ABIN3015343)

Target: Patched 1 (PTCH1)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Patched 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Produktdetails anti-Patched 1 Antikörper

Bindungsspezifität: AA 1214-1312

Sequenz: THSGSDSSDS EYSSQTTVSG LSEELRHYEA QQGAGGPAHQ VIVEATENPV FAHSTVVHPE SRHHPPSNPR QQPHLDSGSL PPGRQGQQPR RDPPREGLW

Kreuzreaktivität: Human, Maus, Ratte

Produktmerkmale: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1214-1312 of human PTCH1 (NP_000255.2).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB,1:500 - 1:1000,IHC,1:50 - 1:100,IF,1:50 - 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu Patched 1

Target: Patched 1 (PTCH1)

Andere Bezeichnung: PTCH1

Hintergrund: This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently.,PTCH1,BCNS,HPE7,NBCCS,PTC,PTC1,PTCH,PTCH11,patched 1,Cancer,Tumor suppressors,Signal Transduction,G protein signaling,Cell Biology & Developmental Biology,Cell Cycle,Cell cycle inhibitors,Hedgehog Signaling Pathway,Neuroscience,Stem Cells,PTCH1

Molekulargewicht: 144 kDa/153 kDa/160 kDa/161 kDa

Gen-ID: 5727

UniProt: Q13635

Pathways: Hedgehog Signalweg, Carbohydrate Homeostasis, Tube Formation